Cenforce 100 mg, which contains sildenafil, works by relaxing blood vessels to increase blood flow to the penis, helping with erectile dysfunction. Nitrates, commonly prescribed for chest pain or heart conditions, also dilate blood vessels. When Cenforce 100 is combined with nitrates, their effects on blood pressure can compound, causing a dangerous and potentially life-threatening drop in blood pressure (hypotension). This can lead to dizziness, fainting, heart attack, or stroke. Even a single dose of either medication can trigger this interaction. Therefore, it is strictly contraindicated to take Cenforce 100 alongside nitrates, and patients should always inform their doctor about all medications they use.